This Factsheet explores common water-related challenges, such as water availability, quality, and management, their associated risks, and relevant policies, while proposing nature-based solutions as a paradigm shift. By outlining key benefits of using nature for an integrated and ecosystem-based water management approach, and best practices in different contexts and ecosystems, the factsheet demonstrates the potential of shifting away from conventional ‘grey’ solutions. Thus, it aims to provide practitioners, developers and policymakers with inspiration, resources and opportunities to increase the uptake of nature-based solutions targeting the ever-growing water-related challenges.