In this paper, they reflect on the implications for science, policy and practice of the recently introduced concept of Nature-Based Solutions (NbS), with a focus on the European context. First, they analyse NbS in relation to similar concepts, and reflect on its relationship to sustainability as an overarching framework. From this, they derive a set of questions to be addressed and propose a general framework for how these might be addressed in NbS projects by funders, researchers, policy-makers and practitioners.